Carbapenem-safe Enterobacteriaceae (CRE) are Gram-negative microorganisms that are impervious to the carbapenem class of anti-infection agents, considered the medications of final resort for such contaminations. They are safe since they create a protein called a carbapenemase that handicaps the medication particle. The protection can fluctuate from direct to extreme. Enterobacteriaceae are normal commensals and irresistible operators. Specialists fear CRE as the new "superbug".The microbes can kill up to half of patients who get circulatory system infections. Tom Frieden, previous leader of the Centers for Disease Control and Prevention has alluded to CRE as "bad dream bacteria".Types of CRE are in some cases known as KPC and NDM . KPC and NDM are catalysts that separate carbapenems and make them incapable. Both of these catalysts, and in addition the protein VIM (Verona Integron-Mediated Metallo-β-lactamase) have additionally been accounted for in Pseudomonas.